Combinatorial Chemistry:

Cracking the right combination through non trial and error methods.

We have a team of scientists who are capable of probing and synthesizing a variety of medicinal products. We understand that New Chemical Entities require new and flexible approach to produce novel building blocks, scaffolds and reference compounds. That’s what our team of scientists brings to our clients. Be it designing the route to proper characterization or scale up of compounds, we wrap up each feat with utmost precision.

Scaffolds / building blocks:

A backbone or a scaffold, in the correct alignment, is important to hold the functional groups for interaction with a biological target. Chembiotek endeavours to deliver the following:

• Synthesis of novel scaffold of any structural complexity.
• Scaffold with 2-4 centers for diversity incorporation.
• Conformationally interesting scaffolds.
• Expertise to synthesize most interesting linear repeating scaffolds- Peptoids and peptides
• TASK (Template Assembled Side Chain)- the conformationally restricted peptides

Libraries:

We have proven expertise on library synthesis in solution as well as on solid phase.

• Synthesis on plates / vials/beads
• Synthetic scale ranging between 5-200mg (each)
• Library size ranging several hundred compounds (each library)
• Synthesis of small focused libraries using both solution phase and solid phase chemistry
• Purity by MS/UV/ELSD detectors
• Low- medium through put automated injectors
• Medium through –put evaporating systems
• Shakers/custom made reaction stations
• Custom formatting to fit the customer's screening, archiving, and processing systems directly with multiple plate formats and plate plus vial formats to create a customized set for compounds