Medicinal Chemistry:

Figuring out the on-screen chemistry of entities.

Truly speaking, we bring to the fore our competencies in the integrated approach of our chemistry and biology expertise. Our team draws on the resource of experienced biologists to bring in innovative services including Lead generation / Lead optimisation / SAR and Synthesis of novel compounds. All these come at affordable cost.

Our medicinal chemistry team proffers the following services:

• Lead generation / Lead optimization / SAR .
• Synthesis of novel compounds.

Lead Generation

Designing, synthesis and screening of a series of compounds are taken care by Chembiotek. The company offers highest quality supports to its collaborators with its own expertise, cost-effective and custom synthesis solution to enhance lead discovery and lead optimization efforts.

• Available programs enable the scientists to generate the QSAR for the compounds to the target binding sites.
• CoMFA , Apex-3D programs allows to identify the NCEs form the analysing the data base generated topological (2D) and topographical (3D) analysis and the biological activity.
• To generate libraries of structurally related compounds (derivatives or close structural analogs, bioisosters or 3D-analogs) based on the activity data supplied by the collaborator.
• Traditional synthesis of complex molecules.
• Combinatorial synthesis of lead libraries.
• Quick analoging of core skeleton using combichem infra structure
• Analysis and purity check to avoid “ false positive”.

Lead Optimization and Structure Activity Relationship (SAR) studies

Lead Optimization in drug discovery is a stepwise, multi-effort process that is under way to find a lead molecule from the “hit” library. Chembiotek, having broad experiences in various field of synthetic and medicinal chemistry is a trustworthy partner in your journey from “hit-to-lead” molecules in drug discovery research.

• Use of molecular modeling infrastructure /expertise in SAR.
• Synthesis of small focused libraries.
• A team effort of individuals having several years of experience in won field of activities.