Associating genomic targets with human disease is a priority for new drug discovery. A number of factors combine to make target and hypothesis validation efficient in India. Chembiotek and its sister organizations, The Centre for Genomics Applications, a core facility for genomics and ClinInvent, a clinical trials CRO, have pooled their expertise and resource base to create clinical genomics services that can be used to address client needs.

CLINICAL GENOMICS - India advantage

A number of founder populations
Large family sizes
Large patient loads across all common diseases
Excellent hospitals with experienced clinicians
State-of-the-art diagnostics.
Competent histopathologists

ACHIEVEMENTS OF OUR CLINICAL GENOMICS TEAM

SNP consortium of India – discovery and validation of SNPs

Sequence based HLA typing of human hematopoetic stem cell repository

Whole genome scans (10 cM) for LD study for a neurological disorder

Microarray studies to identify blood expressed genes

Recruitment, management of Phase III Clinical trial for a top-tier pharmaceutical firm

Human whole blood assays for the evaluation of NCEs

Analysis of FFPE blocks to look at gene expression in solid tumors

CLINICAL CAPABILITIES

Large network of physicians for specific recruitment in desired therapeutic areas

Association with large hospitals to source patient data and samples

GCP based collection – informed consent, patient and family histories

Clinical laboratory work up for tests of various kinds –biochemical, histological etc.

GENOMICS CAPABILITIES

High Throughput Sequencing Service
Whole Genome, Libraries & Genes

Re-sequencing
Mutation Detection & SNP Discovery

Sequence Based Identification
HLA, Viral Genotypes, Microbial Strains

Whole Genome Scans
Linkage Mapping Set v2.5 Genome

Custom Markers
AFLP

SNP Validation and Screening
Mutation Detection & SNP Discovery

Custom Fragment Analysis Applications